AustralieFrV1, Main, Exploration, bibRecord, 000564

Pregnancy outcomes after maternal varenicline use; analysis of surveillance data collected by the European Network of Teratology Information Services.

Identifieur interne : 000564 ( Main/Exploration ); précédent : 000563; suivant : 000565

Pregnancy outcomes after maternal varenicline use; analysis of surveillance data collected by the European Network of Teratology Information Services.

Auteurs : J L Richardson [Royaume-Uni] ; S. Stephens [Royaume-Uni] ; L M Yates [Royaume-Uni] ; O. Diav-Citrin [Israël] ; J. Arnon [Israël] ; D. Beghin [France] ; A. Kayser [Allemagne] ; D. Kennedy [Australie] ; D. Cupitt [Australie] ; B. Te Winkel [Pays-Bas] ; M. Peltonen [Finlande] ; Y C Kaplan [Turquie] ; S H L. Thomas [Royaume-Uni]

Source :

Reproductive toxicology (Elmsford, N.Y.) [ 1873-1708 ] ; 2017.

RBID : pubmed:27851994

Abstract

Varenicline is a smoking cessation aid for which limited data exist concerning safety during human pregnancy. This multicentre prospective observational comparative cohort study was undertaken using surveillance data collected by the European Network of Teratology Information Services. The study sample consisted of 89 varenicline exposed pregnancies and two matched comparator groups; 267 non-teratogen exposed (NTE) controls and 78 exposed to nicotine replacement therapy or bupropion (NRT/B) for smoking cessation. For all exposed pregnancies, varenicline use only occurred in the first trimester, with a considerable proportion discontinuing use in the very early stages of pregnancy. The major congenital malformation rate (n=2/89, 2.25%) was in keeping with the expected background rate (2-4%), and was not significantly increased for first trimester varenicline-exposed infants in comparison with non-exposed controls (vs. NTE: OR 2.02, 95%CI 0.166 to 17.9, vs.

DOI: 10.1016/j.reprotox.2016.11.010
PubMed: 27851994

Affiliations:

Allemagne, Australie, Finlande, France, Israël, Pays-Bas, Royaume-Uni, Turquie
Berlin, Nouvelle-Galles du Sud, Île-de-France
Berlin, Paris, Sydney

Le document en format XML

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<front><div type="abstract" xml:lang="en">Varenicline is a smoking cessation aid for which limited data exist concerning safety during human pregnancy. This multicentre prospective observational comparative cohort study was undertaken using surveillance data collected by the European Network of Teratology Information Services. The study sample consisted of 89 varenicline exposed pregnancies and two matched comparator groups; 267 non-teratogen exposed (NTE) controls and 78 exposed to nicotine replacement therapy or bupropion (NRT/B) for smoking cessation. For all exposed pregnancies, varenicline use only occurred in the first trimester, with a considerable proportion discontinuing use in the very early stages of pregnancy. The major congenital malformation rate (n=2/89, 2.25%) was in keeping with the expected background rate (2-4%), and was not significantly increased for first trimester varenicline-exposed infants in comparison with non-exposed controls (vs. NTE: OR 2.02, 95%CI 0.166 to 17.9, vs.</div>
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Pregnancy outcomes after maternal varenicline use; analysis of surveillance data collected by the European Network of Teratology Information Services.

Pregnancy outcomes after maternal varenicline use; analysis of surveillance data collected by the European Network of Teratology Information Services.

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Abstract

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	Serveur d'exploration sur les relations entre la France et l'Australie
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.